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Urease metabolizes urea into ammonia and carbon dioxide: Urea → 2NH 3 + CO 2.
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The use of 1800 mg of extended-release gabapentin (Gralise), administered once daily, as compared to 1800 mg of immediate-release gabapentin, administered as 600 mg three times daily, resulted in higher Cmax (9.585 +/- 2.326 ng/mL vs 8.536 +/- 1.715 ng/mL) and longer median time to achieve maximal plasma concentrations (8 [range: 3—12] hours vs 2 [range: 1—5] hours). Hyperglycemia has been reported as well and is possibly due to beta-2 receptor blockade in the beta cells of the pancreas.
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